Selected Publications


Chatzinikolaou G, Stratigi K, Siametis A, Goulielmaki E, Akalestou-Clocher A, Tsamardinos I, Topalis P, Austin C, Bouwman BAM, Crosetto N, Altmüller J, Garinis GA. XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes. Sci Adv. 2023 Nov 10;9(45):eadi2095. doi: 10.1126/sciadv.adi2095. Epub 2023 Nov 8. PMID: 37939182

Ourania Chatzidoukaki, Kalliopi Stratigi, Evi Goulielmaki, George Niotis, Alexia Akalestou-Clocher, Katerina Gkirtzimanaki, Alexandros Zafeiropoulos, Janine Altmüller, Pantelis Topalis, and George A. Garinis (2021). R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage. Science Advances 2021 Nov 19;7(47)

Evi Goulielmaki, Maria Tsekrekou, Nikos Batsiotos, Mariana Ascensão-Ferreira, Eleftheria Ledaki, Kalliopi Stratigi, Georgia Chatzinikolaou, Pantelis Topalis, Theodore Kosteas, Janine Altmüller, Jeroen A Demmers, Nuno L Barbosa-Morais, George A Garinis (2021) The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing Nat Commun. 2021 May 26;12(1):3153

Goulielmaki E, Ioannidou A, Tsekrekou M, Stratigi K, Poutakidou IK, Gkirtzimanaki K, Aivaliotis M, Evangelou K, Topalis P, Altmüller J, Gorgoulis VG, Chatzinikolaou G, Garinis GA. "Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage. Nat Commun. 2020 Jan 2;11(1):42.

Chatzinikolaou G, Apostolou Z, Aid-Pavlidis T, Ioannidou A, Karakasilioti I, Papadopoulos GL, Aivaliotis M, Tsekrekou M, Strouboulis J, Kosteas T, Garinis GA. (2017) ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nature Cell Biology 19:421-432.

Karakasilioti I, Kamileri I, Chatzinikolaou G, Kosteas T, Vergadi E, Robinson AR, Tsamardinos I, Rozgaja TA, Siakouli S, Tsatsanis Ch, Niedernhofer LJ, Garinis GA. (2013) DNA damage triggers a chronic auto-inflammatory response leading to fat depletion in NER progeria. Cell Metab. 18:403-15.

Kamileri I, Karakasilioti I, Sideri A, Kosteas T, Tatarakis A, Talianidis I, Garinis GA. Defective transcription initiation causes postnatal growth failure in a mouse model of NER progeria. (2012) Proceedings of the National Academy of Sciences, USA 109:2995-3000.

Garinis GA, Uittenboogaard LM, van IJcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Hoeijmakers JHJ, Schumacher B. (2009) Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nature Cell Biology 11:604-15.

Garinis GA, Gijsbertus van der Horst, Hoeijmakers JH. (2008) DNA damage and aging: new-age ideas for an age-old problem. Nature Cell Biology 10:1241-7.