Selected Publications


A. Siametis, K. Stratigi, D. Giamaki, G. Chatzinikolaou, A. Akalestou-Clocher, E. Goulielmaki, B. Luke, B. Schumacher, G.A. Garinis. Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence, Nature Communications, 15 (2024) 4061.

Arvanitaki ES, Goulielmaki E, Gkirtzimanaki K, Niotis G, Tsakani E, Nenedaki E, Rouska I, Kefalogianni M, Xydias D, Kalafatakis I, Psilodimitrakopoulos S, Karagogeos D, Schumacher B, Stratakis E, Garinis GA. Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2317402121. doi: 10.1073/pnas.2317402121. Epub 2024 Apr 18. PMID: 38635632

Chatzinikolaou G, Stratigi K, Siametis A, Goulielmaki E, Akalestou-Clocher A, Tsamardinos I, Topalis P, Austin C, Bouwman BAM, Crosetto N, Altmüller J, Garinis GA. XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes. Sci Adv. 2023 Nov 10;9(45):eadi2095. doi: 10.1126/sciadv.adi2095. Epub 2023 Nov 8. PMID: 37939182

Ourania Chatzidoukaki, Kalliopi Stratigi, Evi Goulielmaki, George Niotis, Alexia Akalestou-Clocher, Katerina Gkirtzimanaki, Alexandros Zafeiropoulos, Janine Altmüller, Pantelis Topalis, and George A. Garinis (2021). R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage. Science Advances 2021 Nov 19;7(47)

Evi Goulielmaki, Maria Tsekrekou, Nikos Batsiotos, Mariana Ascensão-Ferreira, Eleftheria Ledaki, Kalliopi Stratigi, Georgia Chatzinikolaou, Pantelis Topalis, Theodore Kosteas, Janine Altmüller, Jeroen A Demmers, Nuno L Barbosa-Morais, George A Garinis (2021) The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing Nat Commun. 2021 May 26;12(1):3153

Goulielmaki E, Ioannidou A, Tsekrekou M, Stratigi K, Poutakidou IK, Gkirtzimanaki K, Aivaliotis M, Evangelou K, Topalis P, Altmüller J, Gorgoulis VG, Chatzinikolaou G, Garinis GA. "Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage. Nat Commun. 2020 Jan 2;11(1):42.

Chatzinikolaou G, Apostolou Z, Aid-Pavlidis T, Ioannidou A, Karakasilioti I, Papadopoulos GL, Aivaliotis M, Tsekrekou M, Strouboulis J, Kosteas T, Garinis GA. (2017) ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nature Cell Biology 19:421-432.

Karakasilioti I, Kamileri I, Chatzinikolaou G, Kosteas T, Vergadi E, Robinson AR, Tsamardinos I, Rozgaja TA, Siakouli S, Tsatsanis Ch, Niedernhofer LJ, Garinis GA. (2013) DNA damage triggers a chronic auto-inflammatory response leading to fat depletion in NER progeria. Cell Metab. 18:403-15.

Kamileri I, Karakasilioti I, Sideri A, Kosteas T, Tatarakis A, Talianidis I, Garinis GA. Defective transcription initiation causes postnatal growth failure in a mouse model of NER progeria. (2012) Proceedings of the National Academy of Sciences, USA 109:2995-3000.

Garinis GA, Uittenboogaard LM, van IJcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Hoeijmakers JHJ, Schumacher B. (2009) Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nature Cell Biology 11:604-15.

Garinis GA, Gijsbertus van der Horst, Hoeijmakers JH. (2008) DNA damage and aging: new-age ideas for an age-old problem. Nature Cell Biology 10:1241-7.